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Griseofulvin is an antifungal
antibiotic. It inhibits cell division and DNA production of the
fungi. It is active against the common dermatophytes, including some species of Epidermophyton, Microsporum, or Trichophyton.
Indications
Griseofulvin is used in the treatment of infections of the scalp, hair, nails, and skin that does not respond to topical treatment.
Griseofulvin may also be beneficial in treating infections in the soles of the feet, palms of the hands, and nails.
Composition
Each tablet contains Griseofulvin 125mg
Dosage
The usual dosage for adults is 500mg to 1g daily in single or
divided doses Children may be given 10mg per kg body-weight
daily. The duration of treatment could be 2 to 6 weeks for
infections of the hair and skin, up to 6 months for infections
of the fingernails, and 12 months or more for infections of the
toenails. Griseofulvin is best given with or after meals.
Contraindications
Griseofulvin is contraindicated in patients with severe liver disease or systemic lupus erythematosus (a systemic disease whereby the body's immune system attacks the body's own cells).
Griseofulvin is also contraindicated in pregnancy. Women should
not become pregnant during or within 1 month of stopping
Griseofulvin treatment. For similar reasons, men receiving
Griseofulvin should not father children within 6 months of
treatment. |
