Chlorpheniramine Maleate

Chlorpheniramine maleate is a sedating antihistamine. Chlorpheniramine maleate is used for the symptomatic relief of allergic conditions including urticaria, rhinitis, watery and itchy eyes, coughs, colds, and in pruritic skin disorders.

Composition
Chlorpheniramine Maleate BP � 4mg

Dosage
Adults: Chlorpheniramine maleate tablets are given by mouth in doses of 4mg every 4 to 6 hours (maximum 24mg daily)
Children: 1 to 2 years, 1mg two times daily; 2 to 5 years, 1mg every 4 to 6 hours (maximum 6mg daily) 6 to 12 years, 2mg every 4 to 6 hours (maximum 12mg daily).

Contraindications
Should not be used in patients with conditions such as angle-closure glaucoma, urinary retention, prostatic hyperplasia, or pyloroduodenal obstruction. Should not be given to children below 2 years.

Warnings and Precautions
The maximum recommended dose should not be exceeded. Drowsiness may occur and persist for hours. Patients must not drive or operate machinery when taking Chlorpheniramine maleate tablets. Should not be taken with alcohol or other drugs with respiratory depressant effect.

Side Effects
May cause drowsiness, lassitude, dizziness and incoordination, dry mouth, constipation, gastric reflux.

Drug Interactions
Chlorpheniramine Maleate tablets may interact with barbiturates, hypnotics, opiod analgesics, anxiolytic sedatives, antipsychotics, antimuscarinic drugs, such as atropine and some antidepressants.

Overdose
Overdosage may result in excitement, tremors, psychoses, raised body temperature, hallucinations and convulsions. Coma and cardio-respiratory collapse may follow. Symptomatic management of the anti-muscarinic effects is recommended.

Storage
The tablets should be stored below 30⁰C and away from moisture and light.

 

 
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